May 1998

Generic Prednisolone Suspension Substitution

Author Affiliations

Copyright 1998 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1998

Arch Ophthalmol. 1998;116(5):703. doi:

It is an important consideration for all health care practitioners to be aware of generic medication problems in this environment of generic and therapeutic drug substitution. While regulations governing the manufacture of generic products require that all products meet certain uniform standards, careful postmarketing surveillance is essential in assuring such standards. We recently encountered problems with a generic 1% prednisolone acetate ophthalmic suspension when our buying group switched from a brand name to a generic product considered more cost-effective. Previously, the name brand Pred Forte (1% prednisolone acetate suspension, Allergan, Irvine, Calif) had always been purchased and dispensed at our institutions. Pred Forte, a suspension, requires shaking by the patient prior to use and generally goes into suspension easily with minimal shaking.

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