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Allogeneic cultivated limbal epithelial transplantation (CLET), including living-related CLET, is recommended for bilateral cases with limbal stem cell deficiency or for unilateral cases in which the patient wishes to preserve the limbal function of the healthy fellow eye. For a long-term successful corneal epithelial restoration, it is important to maintain a suitable ocular surface environment and to prevent allograft rejection. Previous reports1- 3 on allogeneic CLET have indicated only the incidence of allograft rejection, with no information on the clinical course or on anterior segment findings. We previously examined 13 patients who underwent allogeneic CLET without any episodes of allograft rejection.2 The details of the epithelial sheet preparation and CLET procedures have also been outlined previously.4 Thereafter, we performed 37 allogeneic CLET procedures in 31 eyes and experienced 3 rejection episodes in 2 eyes with characteristic clinical manifestations. Herein, we describe 2 cases who developed clinically significant allograft rejection reactions.
Satake Y, Dogru M, Yamaguchi T, Tomida D, Hirayama M, Shimazaki J. Immunological Rejection Following Allogeneic Cultivated Limbal Epithelial Transplantation. JAMA Ophthalmol. 2013;131(7):920-922. doi:10.1001/jamaophthalmol.2013.15