Case Report/Case Series
July 2013

Immunological Rejection Following Allogeneic Cultivated Limbal Epithelial Transplantation

Author Affiliations
  • 1Department of Ophthalmology, Tokyo Dental College, Chiba, Tokyo, Japan
  • 2Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan

Copyright 2013 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA Ophthalmol. 2013;131(7):920-922. doi:10.1001/jamaophthalmol.2013.15

Allogeneic cultivated limbal epithelial transplantation (CLET), including living-related CLET, is recommended for bilateral cases with limbal stem cell deficiency or for unilateral cases in which the patient wishes to preserve the limbal function of the healthy fellow eye. For a long-term successful corneal epithelial restoration, it is important to maintain a suitable ocular surface environment and to prevent allograft rejection. Previous reports13 on allogeneic CLET have indicated only the incidence of allograft rejection, with no information on the clinical course or on anterior segment findings. We previously examined 13 patients who underwent allogeneic CLET without any episodes of allograft rejection.2 The details of the epithelial sheet preparation and CLET procedures have also been outlined previously.4 Thereafter, we performed 37 allogeneic CLET procedures in 31 eyes and experienced 3 rejection episodes in 2 eyes with characteristic clinical manifestations. Herein, we describe 2 cases who developed clinically significant allograft rejection reactions.

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