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Case Report/Case Series
July 2013

DacryopsA Series of 5 Cases and a Proposed Pathogenesis

Author Affiliations
  • 1Department of Ophthalmology, University of Ottawa, The Ottawa Hospital, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
  • 2Department of Pathology, University of Ottawa, The Ottawa Hospital, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
JAMA Ophthalmol. 2013;131(7):929-932. doi:10.1001/jamaophthalmol.2013.1885
Abstract

Importance  Lacrimal gland ductal cysts (dacryops) are uncommon, occurring anywhere that lacrimal gland tissue is present. While dacryops has long been recognized, its pathogenesis has not been well established.

Observations  Five cases of dacryops were identified at the Ottawa Hospital over a 3-year period (2009-2012). Histopathological examination showed immunoreactivity to IgA on the luminal surface of the epithelial ductal cyst and mild chronic inflammation in the underlying stroma or lacrimal gland.

Conclusions and Relevance  Our results suggest that a multifactorial mechanism leads to dacryops including chronic inflammation, an immune response, and IgA hypersecretion with an osmotic effect, all contributing to the cyst formation. Further research on the pathogenesis is recommended.

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