June 2011

Vitamin E and Age-Related Cataracts—Reply

Author Affiliations

Author Affiliations: Division of Preventive Medicine, Department of Medicine, Boston, Massachusetts.


Copyright 2011 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2011

Arch Ophthalmol. 2011;129(6):805-820. doi:10.1001/archophthalmol.2011.107

In reply

While it is possible that a higher dose of vitamin E than that tested in Physicians' Health Study II1 (400 IU of synthetic vitamin E every other day) may be required to reduce the incidence of age-related cataract, the dose tested1 exceeded doses associated with lower risks of cataract in observational studies. Similar null results for cataract were observed in the Women's Health Study,2 which tested natural-source vitamin E (600 IU every other day).