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Most glaucoma medications (and surgical procedures) preserve vision by lowering intraocular pressure (IOP).1 Some of these medications (eg, pilocarpine hydrochloride) work by increasing aqueous humor outflow. The trabecular meshwork and the uveoscleral outflow pathway are well-known targets for increasing aqueous outflow. Recently, ocular lymphatics have been identified in human and sheep eyes,2 and these channels also are involved in aqueous humor outflow and IOP regulation.3
Zarbin MA. A New Target for Glaucoma Therapy. JAMA Ophthalmol. Published online October 10, 2013-. doi:10.1001/jamaophthalmol.2013.6867