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October 10, 2013

A New Target for Glaucoma Therapy

Author Affiliations
  • 1Institute of Ophthalmology and Visual Science, Rutgers–New Jersey Medical School, Newark, New Jersey

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JAMA Ophthalmol. Published online October 10, 2013. doi:10.1001/jamaophthalmol.2013.6867

Most glaucoma medications (and surgical procedures) preserve vision by lowering intraocular pressure (IOP).1 Some of these medications (eg, pilocarpine hydrochloride) work by increasing aqueous humor outflow. The trabecular meshwork and the uveoscleral outflow pathway are well-known targets for increasing aqueous outflow. Recently, ocular lymphatics have been identified in human and sheep eyes,2 and these channels also are involved in aqueous humor outflow and IOP regulation.3

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