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Comment & Response
February 2014

Regarding Macular Xanthophylls and ω-3 Long-Chain Polyunsaturated Fatty Acids in Age-Related Macular Degeneration

Author Affiliations
  • 1Department of Chemical and Life Sciences, Macular Pigment Research Group, Waterford Institute of Technology, Waterford, Ireland
JAMA Ophthalmol. 2014;132(2):230-231. doi:10.1001/jamaophthalmol.2013.6667

To the Editor We read with interest the recently published article by Arnold et al titled “Macular Xanthophylls and ω-3 Long-Chain Polyunsaturated Fatty Acids in Age-Related Macular Degeneration: A Randomized Trial.”1 The authors report the results of a 12-month intervention with macular xanthophylls and ω-3 long-chain polyunsaturated fatty acids in patients with nonexudative age-related macular degeneration (AMD), where the main outcome measures included plasma xanthophyll concentrations and optical density of macular pigment (MP). Unfortunately, however, the methods used to assess these outcome measures were flawed, thereby rendering the conclusion of the article unsafe.

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