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Editorial
April 2014

Safety and Complications of OcriplasminOcriplasmin, Ocriplasmin; Oh, How Safe Art Thou?

Author Affiliations
  • 1Department of Ophthalmology, The Eye Institute, Medical College of Wisconsin, Milwaukee
JAMA Ophthalmol. 2014;132(4):379-380. doi:10.1001/jamaophthalmol.2014.278

Our ability to examine the vitreoretinal interface has been greatly improved by the invention of spectral-domain optical coherence tomography (OCT). It has allowed earlier and more accurate diagnosis of abnormalities of vitreomacular adhesion (VMA) that may contribute to vision loss and may benefit from intervention. While subtle abnormalities of VMA may be observed, symptomatic VMA or that associated with full-thickness macular hole (FTMH) requires surgical intervention.1 With improvements in vitreoretinal surgical techniques and better understanding of these conditions, outcomes of surgical management of VMA-related disorders are excellent.1 However, even in the hands of the most experienced surgeon, there are associated surgical risks. There is also expected discomfort to the patient, delay in visual recovery, high cost, and, in cases of surgery for FTMH, postoperative positioning. Furthermore, advanced surgical skills are required for epiretinal membrane or internal limiting membrane peeling.

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