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Central retinal vein occlusion (CRVO) severely threatens vision, especially in ischemic CRVO, for which no effective treatment has been established. Photocoagulation is the only treatment for retinal ischemia, which restores a balance between oxygen supply and demand by reducing the number of retinal cells. Considering its destructiveness, photocoagulation is not ideal. We report 2 cases with ischemic CRVO in which reperfusion of large ischemic areas occurred after novel treatment with an intraocular injection of activated protein C (APC).
Kamei M, Matsumura N, Suzuki M, Sakimoto S, Sakaguchi H, Nishida K. Reperfusion of Large Ischemic Areas Associated With Central Retinal Vein OcclusionA Potential Novel Treatment With Activated Protein C. JAMA Ophthalmol. 2014;132(3):361-362. doi:10.1001/jamaophthalmol.2013.6334