In Reply Dr Kostis and Ms Dobrzynski suggest that cataract surgery would be a better hard end point than clinical diagnoses of cataract. We agree; however, this outcome requires a longer follow-up period than was available in our study (approximately 4.5 years). They also propose that statin effects may vary with patients’ age and stage of cataract development. We appreciate these ideas and agree that such a study should be pursued. Owing to the relatively small sample size of our propensity score–matched cohort, further subgroup analysis was not feasible.
Mansi I, Leuschen J, Mortensen EM. Statin Use and Cataract—Reply. JAMA Ophthalmol. 2014;132(3):364-365. doi:10.1001/jamaophthalmol.2014.40