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April 2014

Varicella-Zoster Virus Detection in Varicella-Associated Stromal Keratitis

Author Affiliations
  • 1Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, Texas
  • 2Department of Pathology and Genomic Medicine, Houston Methodist Hospital and Weill Medical College of Cornell University, Houston, Texas
JAMA Ophthalmol. 2014;132(4):505-506. doi:10.1001/jamaophthalmol.2013.8254

Stromal keratitis is a well-known development in herpes zoster ophthalmicus but is uncommonly noted following varicella, the primary infection with varicella-zoster virus.1 Keratitis typically occurs several weeks to months following varicella and is often described as disciform in nature. We describe a case of varicella-associated stromal keratitis in which the cornea was positive for varicella-zoster virus by polymerase chain reaction (PCR) testing. We believe that this is the first case of varicella-associated stromal keratitis documented by identification of varicella-zoster virus in the cornea.

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