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Observation
April 2014

Rapid Progression of Uveitis and Alopecia Syphilitica in AIDS

Author Affiliations
  • 1Keck School of Medicine, University of Southern California, Los Angeles
  • 2Doheny Eye Institute, University of Southern California, Los Angeles
JAMA Ophthalmol. 2014;132(4):506-508. doi:10.1001/jamaophthalmol.2014.7

There has been recent renewed interest in the ocular manifestations of syphilis, likely owing to the increased prevalence of patients with human immunodeficiency virus (HIV) coinfections in recent years. Ocular complications due to syphilis in these immunocompromised patients have been noted not only to progress faster but also to be more severe.1,2 We describe a young man, ultimately diagnosed as having syphilis and AIDS, who presented with florid panuveitis in the setting of progressive, secondary syphilitic dermatologic findings including alopecia of the scalp, eyebrows, and eyelashes, oral ulcers, and maculopapular rash of the face.

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