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Observation
October 2014

Adenocarcinoma of the Retinal Pigment EpitheliumClinicopathologic Correlation With Paradoxical Immunohistochemical Findings

Author Affiliations
  • 1Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania
  • 2Department of Pathology, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania
  • 3Department of Ophthalmology, University of North Carolina, Chapel Hill
  • 4Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania
JAMA Ophthalmol. 2014;132(10):1249-1252. doi:10.1001/jamaophthalmol.2014.2369

True neoplasms can arise from pigment epithelium of the iris, ciliary body, and retina (retinal pigment epithelium [RPE]).14 We report a large adenocarcinoma of RPE that was a diagnostic challenge based on clinical features, cytopathology, and immunohistochemistry. However, with routine histopathology of the enucleated eye, the diagnosis of RPE adenocarcinoma was established.

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