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October 2014

Regression of Choroidal Metastasis From Breast Carcinoma Treated With Gamma Knife Radiosurgery

Author Affiliations
  • 1New England Eye Center, Tufts Medical Center, Boston, Massachusetts
  • 2Department of Radiation Oncology, Tufts Medical Center, Boston, Massachusetts
  • 3Department of Ophthalmology, The Aroostook Medical Center, Presque Isle, Maine

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JAMA Ophthalmol. 2014;132(10):1248-1249. doi:10.1001/jamaophthalmol.2014.1974

Uveal metastasis is often managed by external beam radiation therapy requiring multiple treatment sessions for the patient. We report the first case, to our knowledge, of regression of choroidal metastasis from breast carcinoma after 1 treatment with Leksell Gamma Knife (GK) stereotactic radiosurgery.

A woman in her late 40s presented with a 1-month history of visual distortion in the left eye. Medical history was significant for stage IIA ductal breast carcinoma diagnosed 14 years previously. Her disease was controlled during a 10-year period with mastectomy and hormonal therapy until she developed a metastatic pleural effusion, which was confirmed by thoracentesis. She was treated for 6 months up to presentation with exemestane with good response.

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