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Comment & Response
September 2014

Outer Segment Length in Different Best Disease Genotypes

Author Affiliations
  • 1Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City
JAMA Ophthalmol. 2014;132(9):1152-1153. doi:10.1001/jamaophthalmol.2014.2980

To the Editor We were interested to read the recent article by David B. Kay et al1 in which adaptive optics scanning laser ophthalmoscopy and spectral-domain optical coherence tomography (SD-OCT) were used to study the retinas of 4 patients with the Arg218Cys mutation in BEST1. The application of adaptive optics scanning laser ophthalmoscopy to Best disease and other inherited macular diseases is contributing exciting new information on the photoreceptor mosaic that was previously unavailable, and the authors are commended for their innovative approach and their intriguing findings related to Best disease pathophysiology.

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