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Comment & Response
September 2014

Outer Segment Length in Different Best Disease Genotypes—Reply

Author Affiliations
  • 1Department of Ophthalmology, Medical College of Wisconsin, Milwaukee
  • 2Department of Biomedical Engineering, Marquette University, Milwaukee, Wisconsin
  • 3Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee
  • 4Department of Biophysics, Medical College of Wisconsin, Milwaukee
JAMA Ophthalmol. 2014;132(9):1153. doi:10.1001/jamaophthalmol.2014.2984

In Reply We agree that genotype-phenotype differences in patients with BEST1 mutations are poorly understood and may underlie the apparent differences between the 2 studies. Furthermore, light adaptation at the time of SD-OCT imaging acquisition can affect the appearance of the outer retinal bands, as shown recently by Abràmoff et al1 and Godara et al.2 As we did not control for light adaptation at the time of SD-OCT imaging acquisition in patients with Best vitelliform macular dystrophy, this might also explain the different results.

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