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Diabetic macular edema can be resistant to anti–vascular endothelial growth factor (VEGF) therapy, and long-term consequences of VEGF suppression are not well understood.1 Previous studies in central retinal vein occlusion have associated exudative retinal detachment with increased production of VEGF and interleukin 6,2 and localized central serous retinal detachment has been described in diabetic retinopathy.3,4 We observed a patient with chronic diffuse diabetic macular edema who developed extensive bilateral exudative retinal detachment after cessation of long-term anti-VEGF therapy.
Michelotti MM, Jain N, Johnson MW. Bilateral Exudative Retinal Detachment in a Diabetic Patient With Severe Peripheral Retinal Ischemia. JAMA Ophthalmol. 2015;133(1):107-109. doi:10.1001/jamaophthalmol.2014.3491