To the Editor We read with interest the article by Kamei et al1 reporting reperfusion of ischemic regions of the retina in 2 patients with central retinal vein occlusion (CRVO). The reperfusion illustrated by the authors is quite impressive, and we look forward to larger studies on the efficacy of activated protein C in patients with ischemic CRVO.
In their article, Kamei and colleagues mentioned that “reperfusion in ischemic CRVO has not been reported previously.”1 Although it is true that some earlier studies have reported either no change or increases in the areas of retinal nonperfusion (RNP),2,3 others have reported decreases in areas of RNP in some patients with CRVO or branch retinal vein occlusion.4,5
Tan CS, Chew MC, Sadda SR. Reperfusion of Areas of Ischemia in Central Retinal Vein Occlusion. JAMA Ophthalmol. 2015;133(2):227-228. doi:10.1001/jamaophthalmol.2014.4245