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Comment & Response
February 2015

Reperfusion of Areas of Ischemia in Central Retinal Vein Occlusion

Author Affiliations
  • 1National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore
  • 2Doheny Eye Institute, University of Southern California, Los Angeles
JAMA Ophthalmol. 2015;133(2):227-228. doi:10.1001/jamaophthalmol.2014.4245

To the Editor We read with interest the article by Kamei et al1 reporting reperfusion of ischemic regions of the retina in 2 patients with central retinal vein occlusion (CRVO). The reperfusion illustrated by the authors is quite impressive, and we look forward to larger studies on the efficacy of activated protein C in patients with ischemic CRVO.

In their article, Kamei and colleagues mentioned that “reperfusion in ischemic CRVO has not been reported previously.”1 Although it is true that some earlier studies have reported either no change or increases in the areas of retinal nonperfusion (RNP),2,3 others have reported decreases in areas of RNP in some patients with CRVO or branch retinal vein occlusion.4,5

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