In Reply We thank Spaide for his critical review. He is correct in that data were included for each point at which complete data were available within the study period. Thus, more than 1 set of data points could be included for each patient. His main concern centers on the multiple examinations per patient, that we did not account for these data dependencies in the statistical analysis, and that this would overestimate the significance of the correlations. The purpose of this analysis was to determine whether the presence of suprachoroidal fluid might be a parameter that clinicians can use to follow the activity of patients with birdshot chorioretinopathy. The data set was not large enough for the more rigorous statistical analysis described by Spaide. Furthermore, the conclusions of this article were meant to be hypothesis generating rather than definitive proof. After the original analysis reported in this article, we performed an evaluation of the relationship between the clinical symptom of photopsias and the optical coherence tomographic finding of suprachoroidal fluid in a larger group of patients with longitudinal follow-up. The analysis of these data accounts for the correlations between eyes and over time within a person. The results support the current finding and are being submitted for publication.
Birnbaum AD, Fawzi AA, Goldstein DA. Fourteen Patients With Fifty-Eight Eyes—Reply. JAMA Ophthalmol. 2015;133(3):357-358. doi:10.1001/jamaophthalmol.2014.4659