To the Editor In 2012, Martin et al1 published the results at 2 years of the Comparison of Age-Related Macular Degeneration Treatments Trials and found a nonsignificant difference between bevacizumab and ranibizumab according to the continuous end point of the change in letters of visual acuity (mean difference for bevacizumab vs ranibizumab, −1.4 letters; 95% CI, −3.7 to +0.8 letters; P = .21). More recently, Ying et al2 carried out a multivariate analysis of the same study data in which the bevacizumab group was shown to have higher odds of losing 15 or more letters than the ranibizumab group (odds ratio, 1.83; 95% CI, 1.07 to 3.14; P = .03).
Messori A. Comparative Effectiveness of Bevacizumab and Ranibizumab in the Comparison of Age-Related Macular Degeneration Treatments Trials. JAMA Ophthalmol. 2015;133(3):363-364. doi:10.1001/jamaophthalmol.2014.4642