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Comment & Response
April 2015

Prevention of Hydroxychloroquine-Related Retinal Toxic Effects

Author Affiliations
  • 1John Muir Medical Group, Walnut Creek, California
  • 2Sutter Solano Medical Center, Vallejo, California
JAMA Ophthalmol. 2015;133(4):492. doi:10.1001/jamaophthalmol.2014.3254

To the Editor We commend Mititelu et al1 on their recent study of hydroxychloroquine toxic effects but take issue with their conclusion. We believe prevention rather than early detection is best practice. Hydroxychloroquine is dosed by lean (“ideal”) body weight, which is based purely on height and sex. It is a hypothetical concept that excludes body fat in determining a person’s weight. Hence, shorter patients will have a lower lean body weight.

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