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JAMA Ophthalmology Clinical Challenge
June 2015

Bilateral Choroidal Detachment in Waldenström Macroglobulinemia

Author Affiliations
  • 1Shanghai Aier Eye Hospital, Shanghai, China
  • 2Department of Ophthalmology, University of Florida College of Medicine, Jacksonville
JAMA Ophthalmol. 2015;133(6):715-716. doi:10.1001/jamaophthalmol.2015.64

A woman in her 60s presented with a 1-month history of painless, blurred vision in the left eye. Her medical history was significant for Waldenström macroglobulinemia (WM), and recent laboratory test results showed active WM with bone marrow involvement. Results of the eye examination showed best-corrected visual acuity of 20/20 OD and 20/40 OS. Anterior segment examination results showed a relatively shallow anterior chamber in the left eye. Results of a dilated fundus examination showed a choroidal detachment in the left eye extending circumferentially from the 2-o’clock to the 5-o’clock position and extending posteriorly up to 3 to 4 disc diameters temporal to the macula (Figure, A). There was vitreous hemorrhage with a poor view of the posterior pole (Figure, A).

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