[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.146.179.146. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Views 565
Citations 0
JAMA Ophthalmology Clinical Challenge
October 2015

Under the Guise of Retinitis

Author Affiliations
  • 1Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts
JAMA Ophthalmol. 2015;133(10):1205-1206. doi:10.1001/jamaophthalmol.2015.1926

A man in his 30s presented with a 5-day history of bilateral redness, blurred vision, and photophobia. The patient had received a diagnosis of human immunodeficiency virus (HIV) infection 4 months before, with a nadir in his CD4 count of 11/μL. He started highly active antiretroviral therapy, with improvement in his CD4 count to 101/μL most recently. During the past few months, he had reported increasing fatigue and intermittent fevers thought to be owing to immune reactivation syndrome. In addition to highly active antiretroviral therapy, he received combined sulfamethoxazole and trimethoprim and azithromycin prophylaxis. His visual acuity was 20/150 OD and 20/100 OS, and intraocular pressures were 6 and 10 mm Hg, respectively. On slitlamp examination, both eyes were injected with diffuse mutton-fat keratic precipitates and had more than 50 cells per 1×1-mm slitlamp high-power beam in the anterior chamber. Results of a dilated ophthalmoscopic examination revealed bilateral vitritis, hyperemic optic nerves, and extensive whitening likely involving all layers of the retina (Figure 1). He was hospitalized and started therapy consisting of intravenous (IV) acyclovir sodium, 10 mg/kg every 8 hours, and prednisone, 30 mg/d. Samples for a laboratory workup for infectious causes were obtained. After 48 hours of treatment, his condition did not improve.

First Page Preview View Large
First page PDF preview
First page PDF preview
×