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Observation
October 2015

Bilateral, Multiple, Episodic Retinal Vein Occlusions Associated With Common Variable Immunodeficiency

Author Affiliations
  • 1Retina Division, Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, Maryland
  • 2Retina Associates of Cleveland, Cleveland, Ohio
  • 3Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, Ohio
  • 4Editor, JAMA Ophthalmology
JAMA Ophthalmol. 2015;133(10):1216-1218. doi:10.1001/jamaophthalmol.2015.2414

Common variable immunodeficiency (CVID) is a heterogeneous family of primary immunodeficiencies characterized by reduced serum levels of immunoglobulins with reduced immunity.1 Reported ocular involvement with CVID includes retinal vasculitis,2 placoid choroidopathy,3 and retinal pigmentary alterations.4 In one report, 3 patients with CVID had retinal vasculitis and macular edema.2 Autoimmune disorders are found in 20% of these patients,5 and an association with uveitis has been suggested.6 We describe a patient with CVID who developed bilateral, multiple, episodic retinal vein occlusions, with peripheral retinal neovascularization at the boundary of areas of retinal capillary nonperfusion treated with scatter photocoagulation, and macular edema treated with bevacizumab.

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