In Reply We appreciate the thoughtful comments of Grzybowski and Stacy regarding the use of laboratory markers in deciding whether to perform TAB in patients with possible GCA. We agree that TAB is important not only for establishing the diagnosis of GCA but also for justifying the use of long-term corticosteroid therapy from which nearly all patients will experience adverse effects. Additionally, TAB may confirm the diagnosis in patients with normal laboratory markers but a suspicious clinical picture.
De Lott LB, Burke JF, Trobe JD. Temporal Artery Biopsy in Giant Cell Arteritis—Reply. JAMA Ophthalmol. 2015;133(10):1220-1221. doi:10.1001/jamaophthalmol.2015.2554