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Comment & Response
October 2015

Considerations for Randomizing 1 Eye or 2 Eyes

Author Affiliations
  • 1National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, England
  • 2Cochrane Eyes and Vision Group, London School of Hygiene and Tropical Medicine, London, England
JAMA Ophthalmol. 2015;133(10):1221. doi:10.1001/jamaophthalmol.2015.2757

To the Editor We read the recent article by Glassman and Melia1 with great interest. The authors recommend that careful consideration should be given in ophthalmic clinical trials to enrollment of both eyes when possible and highlight aspects of study design to consider. We support these recommendations but also strongly advise consideration of 2 additional aspects of study design when considering whether the methods should involve randomization of 1 eye or 2 eyes.

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