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Observation
December 2015

Invasive Squamous Cell Carcinoma With Clear Cell Change of the Eyelid Arising in a Seborrheic Keratosis

Author Affiliations
  • 1David G. Cogan Laboratory of Ophthalmic Pathology, Massachusetts Eye and Ear Infirmary, Boston
  • 2Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts
  • 3Ophthalmic Consultants of Boston, Boston, Massachusetts
JAMA Ophthalmol. 2015;133(12):1476-1477. doi:10.1001/jamaophthalmol.2015.3439

Seborrheic keratoses (SKs) are common, often numerous lesions of older patients, having a characteristic greasy, stuck-on appearance.1 They are often thought of as universally benign. Development of a malignant tumor within an SK is indeed a rare event.2 To our knowledge, this is the first report of an invasive squamous cell carcinoma (SCC) arising in an SK in the eyelid skin, a reminder that typical-appearing SKs can harbor a malignant neoplasm.

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