Seborrheic keratoses (SKs) are common, often numerous lesions of older patients, having a characteristic greasy, stuck-on appearance.1 They are often thought of as universally benign. Development of a malignant tumor within an SK is indeed a rare event.2 To our knowledge, this is the first report of an invasive squamous cell carcinoma (SCC) arising in an SK in the eyelid skin, a reminder that typical-appearing SKs can harbor a malignant neoplasm.
Stagner AM, Jakobiec FA, Iwamoto MA. Invasive Squamous Cell Carcinoma With Clear Cell Change of the Eyelid Arising in a Seborrheic Keratosis. JAMA Ophthalmol. 2015;133(12):1476-1477. doi:10.1001/jamaophthalmol.2015.3439