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Comment & Response
December 2015

Accuracy, Reliability, and Consistency in the Collection of Tear Film Osmolarity Data—Reply

Author Affiliations
  • 1Scheie Eye Institute, University of Pennsylvania, Philadelphia
JAMA Ophthalmol. 2015;133(12):1483. doi:10.1001/jamaophthalmol.2015.3897

In Reply Aquavella discusses several possible factors (such as blinking effects and transitions from different environments) that have been studied in laboratory settings and may have contributed to the variability of measurements that we observed in our study.1 However, it is important to note that we conducted our study under conditions that can practically be controlled in a clinical setting and are similar to how the device is typically used in clinical practice. For example, all of our osmolarity testing was carried out in a climate-controlled room with closely monitored temperature and humidity. In addition, we were careful not to induce reflex tearing when obtaining measurements, and all readings were performed in accordance with the manufacturer’s instructions.

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