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The association of maculopathy with advanced glaucomatous cupping is known, but controversy remains over the origin of fluid.1- 3 Reports using enhanced depth imaging have demonstrated a track communicating from cavities posterior to the lamina cribrosa to the peripapillary retina, and these cavities presumably consist of cerebrospinal fluid (CSF).2,3
Patel S, Ling J, Kim SJ, Schey KL, Rose K, Kuchtey RW. Proteomic Analysis of Macular Fluid Associated With Advanced Glaucomatous Excavation. JAMA Ophthalmol. 2016;134(1):108-110. doi:10.1001/jamaophthalmol.2015.4105