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Research Letter
January 2016

Proteomic Analysis of Macular Fluid Associated With Advanced Glaucomatous Excavation

Author Affiliations
  • 1Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee
  • 2Department of Biochemistry, Vanderbilt University, Nashville, Tennessee
  • 3Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee
JAMA Ophthalmol. 2016;134(1):108-110. doi:10.1001/jamaophthalmol.2015.4105

The association of maculopathy with advanced glaucomatous cupping is known, but controversy remains over the origin of fluid.13 Reports using enhanced depth imaging have demonstrated a track communicating from cavities posterior to the lamina cribrosa to the peripapillary retina, and these cavities presumably consist of cerebrospinal fluid (CSF).2,3

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