For nearly 40 years, panretinal photocoagulation (PRP) has been the standard treatment for proliferative diabetic retinopathy (PDR).1 Eyes responding to PRP can remain stable for decades, although incomplete responses and relapses can occur. Although remarkably effective at reducing the risk of ambulatory vision loss (<5/200), PRP destroys viable peripheral retinal tissue resulting in peripheral visual field loss and possible exacerbation of macular edema. Therefore, evaluating new and less destructive therapeutic alternatives, such as anti–vascular endothelial growth factor (anti-VEGF) therapy, is desirable. Several studies using anti-VEGF for diabetic macular edema (DME) have reported improvement of retinal neovascularization (NV)2,3; until now, it was unclear if these beneficial effects could be sustained on eyes with PDR when compared with PRP.
Gross JG, Glassman AR. A Novel Treatment for Proliferative Diabetic RetinopathyAnti–Vascular Endothelial Growth Factor Therapy. JAMA Ophthalmol. 2016;134(1):13-14. doi:10.1001/jamaophthalmol.2015.5079