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Comment & Response
February 2016

Long-term Risk of Melanoma-Related Mortality After Uveal Melanoma

Author Affiliations
  • 1Department of Ophthalmology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
  • 2Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
JAMA Ophthalmol. 2016;134(2):238-239. doi:10.1001/jamaophthalmol.2015.5233

To the Editor In their article titled “Long-term Risk of Melanoma-Related Mortality for Patients With Uveal Melanoma Treated With Proton Beam Therapy,”1 Lane and colleagues addressed 25-year mortality after radiotherapy for uveal melanoma using Kaplan-Meier analysis. Their series is notable for including 3088 patients and for meticulous follow-up. We wish to highlight the need to consider competing risks in this type of analysis. The authors may also have misinterpreted certain aspects of our report on very long-term survival after enucleation for this cancer.2

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