A man in his late 80s underwent a fundus fluorescein angiogram following an ischemic branch retinal vein occlusion. Medical history included hypertension. Five milliliters of sodium fluorescein, 20%, was injected through an intravenous cannula sited in a tributary of the dorsal venous network of the hand. Shortly after injection, yellow forearm venous staining was noted distally from the injection site extending midway up the cephalic vein proximally (Figure). This was completely asymptomatic and no other unexpected adverse effects of the investigation were reported.
Banerjee PJ, Davies NP. An Innocuous Adverse Effect of Routine Fundus Fluorescein Angiography. JAMA Ophthalmol. 2016;134(1):e153624. doi:10.1001/jamaophthalmol.2015.3624