In Reply We agree it remains unclear whether the ocular lesions are or are not a direct result of ZIKV or microcephaly. Actually, even the scientific proof that ZIKV is in fact the cause of microcephaly is still a matter of debate for some. In January 2016, our research group published an article from Recife, Brazil, with similar findings.1 Recife and Salvador are both populous capital cities located on the coast of the Northeast Region of Brazil. They share similar tropical weather and are where the largest ZIKV outbreaks in Brazil took place. Our article published in JAMA Ophthalmology showed large excavated chorioretinal lesions in infants evaluated in Salvador, Bahia, Brazil, that had not been previously described.2 Unpublished studies from other parts of northeastern Brazil confirm the findings in Bahia were unrelated to local conditions.
Belfort R, de Paula Freitas B, de Oliveira Dias JR. Zika Virus, Microcephaly, and Ocular Findings—Reply. JAMA Ophthalmol. 2016;134(8):946-947. doi:10.1001/jamaophthalmol.2016.1305