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To the Editor We greatly appreciate the recent article by de Paula Freitas et al1 outlining the ophthalmic manifestations in infants with presumed congenital Zika virus (ZIKV) infection during an outbreak in Salvador, Bahia, Brazil. The authors have provided important insight into this disease, and their findings will assist clinicians around the world to diagnose congenital ZIKV infection. As noted by the authors, this diagnosis is clinical, as the polymerase chain reaction often used to detect the virus is only of use within the early days of the acute infection and cannot be used in these infantile cases.1
Rasool N, Odel JG. Similarities in the Retinal Appearance of Patients With Zika Virus Compared With Cobalamin C Deficiency. JAMA Ophthalmol. 2016;134(10):1200-1201. doi:10.1001/jamaophthalmol.2016.2398