[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.161.216.242. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Views 122
Citations 0
Observation
October 2016

Diffuse Histiocytic Sarcoma Involving the Choroid

Author Affiliations
  • 1Department of Cellular Pathology, Royal Liverpool and Broadgreen University Hospital Trust, Liverpool, England
  • 2Department of Pathology and Forensic Medicine, Faculty of Medicine–Federal University of Bahia, Salvador, Brazil
  • 3Liverpool Ocular Oncology Centre, Royal Liverpool and Broadgreen University Hospital Trust, Liverpool, England
  • 4Queensland Ocular Oncology Service, Terrace Eye Centre, Brisbane, Australia
  • 5Department Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, England
JAMA Ophthalmol. 2016;134(10):1198-1200. doi:10.1001/jamaophthalmol.2016.2867

Herein, we describe a rare case of histiocytic sarcoma with choroidal involvement with immunohistochemical and genetic confirmation. To our knowledge, this is the first report of histiocytic sarcoma with intraocular involvement in the human eye.

A middle-aged man was admitted to a regional hospital with acute sinusitis, tonsillitis, and increasing dysphagia and dyspnea. Recently, he had been investigated for malaise, generalized lymphadenopathy, and anemia. The patient presented to the ophthalmology department for painless blurred vision in the left eye. On examination, he had a central scotoma in the left eye, but his visual acuity was 6/6 OU. Subtle subretinal fluid in the left eye, consistent with central serous chorioretinopathy, was noted on fundus images and confirmed by ocular coherence tomography. There was no intraocular inflammation; thus, management involved observation. Meanwhile, a histological examination of nasal and bone-marrow biopsies revealed histiocytic sarcoma.

First Page Preview View Large
First page PDF preview
First page PDF preview
×