Corneal epithelial wound healing is a seemingly simplistic process that in reality is quite complex depending on the circumstances: the proliferation, migration, and adhesion of epithelial cells occur differently under various conditions of inflammation, infection, and underlying stromal processes. As such, therapies to heal traumatic corneal abrasions, planned corneal epithelial defects such as postphotorefractive keratectomy (PRK), and persistent epithelial defects (PED) may require addressing different mechanisms. Because of the possible consequences of epithelial defects, such as infection, scarring, corneal melting, and even perforation, all potentially leading to loss of vision, interest in healing corneal epithelial defects is high.
Jeng BH. Abrasions, Planned Defects, and Persistent Epithelial Defects in Corneal Epithelial Wound Healing. JAMA Ophthalmol. 2016;134(10):1176-1177. doi:10.1001/jamaophthalmol.2016.3086