To the Editor We read with interest the recent article by Raguideau et al1 on the association between the use of fluoroquinolone antibiotics and retinal detachment. The authors chose to use 2 self-controlled study designs to address this question: first, the case crossover method,2 and, second, the self-controlled case series.3 The 2 methods appear to give similar answers, suggesting a roughly 50% increased risk of retinal detachment following exposure to a fluoroquinolone. However, we have some concerns about the method underpinning the study.
Douglas IJ, Root A, Krishnan B. Oral Fluoroquinolone Use and Retinal Detachment. JAMA Ophthalmol. 2016;134(12):1448. doi:10.1001/jamaophthalmol.2016.3477