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Invited Commentary
December 2016

Binocular Treatment of Amblyopia in ChildrenTeething Problems on the Path to Clinical Practice

Author Affiliations
  • 1National Institute of Health Research Biomedical Research Centre at Moorfields Eye Hospital and University College London Institute of Ophthalmology, London, England
JAMA Ophthalmol. 2016;134(12):1400-1401. doi:10.1001/jamaophthalmol.2016.3657

Binocular treatments are without doubt the most exciting development in the field of amblyopia. In this issue of JAMA Ophthalmology, Holmes et al1 with the Pediatric Eye Investigator Group (PEDIG) reports the eagerly anticipated results of a randomized clinical trial comparing binocular with standard occlusion treatment. The most important finding from a clinical point of view is that, in children younger than 7 years who have not had previous treatment other than glasses, visual acuity in the amblyopic eye improved by a mean (SD) 2.5 (1.5) lines over 16 weeks compared with 2.8 (0.8) lines in the control group. Unfortunately, this group was only a small subgroup (n = 38) of the overall trial, too small to test for significance. The majority of patients newly referred for amblyopia are younger than 7 years; hence, the particular relevance of this population.

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