Intravenous, intra-arterial, and intravitreous chemotherapy are modern treatments for retinoblastoma that can achieve favorable tumor control and globe salvage without facial disfigurement that may follow external beam radiotherapy.1- 4 A girl in her second year of life with bilateral germline-mutation retinoblastoma received intravenous chemotherapy and subsequent intra-arterial and intravitreous chemotherapy with complete tumor control.
Anderson HJ, Pointdujour-Lim R, Shields CL. Treatments for Retinoblastoma Then and Now. JAMA Ophthalmol. 2017;135(1):e164652. doi:10.1001/jamaophthalmol.2016.4652