Cyclosporine has been used for the treatment of organ transplantation, autoimmune diseases, and uveitis. Because patients with uveitis may have an increase in intraocular pressure, systemic acetazolamide is used concomitantly with cyclosporine treatment. Previous animal studies have shown that concomitant administration of cyclosporine with acetazolamide caused a delay in the clearance of cyclosporine and a marked increase in the blood levels of cyclosporine.1 The main objective of this letter is to report the effects of the coadministration of acetazolamide with cyclosporine among 3 patients.
Tabbara KF, Al-Faisal Z, Al-Rashed W. Interaction Between Acetazolamide and Cyclosporine. Arch Ophthalmol. 1998;116(6):832-833. doi: