FOR MORE than a century, the diagnosis and management of glaucoma has been focused on the measurement of intraocular pressure. However, recently there has been increasing dissatisfaction with reliance on intraocular pressure for both diagnostic and therapeutic purposes. Classifying glaucoma solely on an artificially constructed dichotomy of pressure values has been suggested to be futile.1 Moreover, some patients with glaucoma continue to worsen despite considerable lowering of intraocular pressure. It is evident that other factors that directly damage the optic nerve or increase its susceptibility to damage need to be identified and ameliorated.
Weinreb RN. Toward Understanding the Optic Neuropathy of Glaucoma. Arch Ophthalmol. 1998;116(8):1102-1103. doi:10.1001/archopht.116.8.1102