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Invited Commentary
June 22, 2017

Probing the Role of Inflammation in Age-Related Macular Degeneration

Author Affiliations
  • 1Department of Ophthalmology, University of Alabama at Birmingham, Birmingham
JAMA Ophthalmol. Published online June 22, 2017. doi:10.1001/jamaophthalmol.2017.2008

Because chronic myeloproliferative neoplasms (MPNs) are associated with chronic inflammation, Bak et al1 investigated the incidence of neovascular age-related macular degeneration (AMD) among a population of Danish patients with these tumors.1 Using an age- and sex-matched retrospective cohort study design, they compared the risk of developing AMD in patients with MPN with the risk for the general population. The risk of developing AMD was increased for patients with MPN, with an adjusted hazard ratio of 1.3 (95% CI, 1.1-1.5), and risk increased in all MPN subtypes (essential thrombocythemia, polycythemia vera, myelofibrosis, and unclassifiable).

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