The mechanism of closure of a macular hole (MH) is not yet fully understood. Spontaneous closure in nontraumatic cases is possible, but quite rare.1 Alternatively, vitrectomy and gas tamponade, with or without internal limiting membrane (ILM) peeling, achieve anatomic success in 80% to 95% of cases. During recent years, different techniques have been attempted to improve the closure rate of MH and bring it closer to 100%.
Pertile G, Mete M, Alfano A. Features Involved in the Healing Process of Macular Holes. JAMA Ophthalmol. Published online July 06, 2017. doi:10.1001/jamaophthalmol.2017.2207