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March 2001

Retinal Toxic Effects Associated With Intravitreal Fomivirsen

Author Affiliations

Copyright 2001 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2001

Arch Ophthalmol. 2001;119(3):458. doi:

Amin et al1 are to be commended for bringing to our attention a serious adverse effect of fomivirsen sodium, a phosphorothioate antisense oligonucleotide compound recently approved for the treatment of cytomegalovirus retinitis. Their clinical case report published in the ARCHIVES clearly illustrates the potential for widespread retinal pigment epithelial change. The package label for fomivirsen indicates that in addition to intraocular inflammation, retinal pigment changes may occur. Their case is an example of this and documents severe peripheral vision loss.

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