Parinaud: On the explanation of the pathology of toxic optic neuritis. Toxic substances affect the neuron in its entire course from the periphery to the centres. Why certain poisons affect the optic nerve and only its macular fibres is difficult to explain. Analogies of the selective action of a poison on particular portions of the nervous system are not rare: curare acts on the end plates of the motor nerves, the diphtheria toxin on the muscle of accommodation, etc. Parinaud regards toxic optic neuritis as a special form of disease of the central nervous system in consequence of the action of the poison.
A look at the past . . .. Arch Ophthalmol. 2001;119(5):751. doi:10.1001/archopht.119.5.751