Copyright 2001 American Medical Association. All Rights Reserved.
Applicable FARS/DFARS Restrictions Apply to Government Use.2001
Current treatment of filamentary keratitis (FK)—the presence of
fine filaments composed of epithelial cells and mucus attached to the cornea—includes
lubrication, acetylcysteine, therapeutic contact lenses,1
and mechanical removal of the filaments. Although these methods are usually
effective, the condition can be resistant to treatment and can even cause
complications such as corneal vascularization. We have had success with 0.1%
diclofenac sodium drops, a nonsteroidal, anti-inflammatory compound, in the
treatment of 6 patients with FK. The 6 prospective patients, who gave written
informed consent to participate in the study, ranged in age from 40 years
to 76 years (mean, 61 years). The FK was associated with dry eye in 5 patients
and with corneal edema in 1. Four of them developed filaments several months
after intraocular surgery: 2 after corneal transplantation, 1 after cataract
surgery, and 1 after posterior vitrectomy combined with cataract surgery.
Three patients received the drug as the first and only treatment; for the
other 3 it was added to treatments they had been receiving for 2 to 12 months
without success, including various lubricants, topical steroids, acetylcysteine,
hypertonic solutions, mechanical removal of filaments, and therapeutic contact
lenses. The 0.1% diclofenac sodium was applied topically 4 times a day for
3 to 4 weeks. Within 1 to 2 weeks of initial treatment, the filaments had
disappeared from the corneas of all 6 patients. During the 8 months of follow-up,
there were no recurrences of filaments and no adverse reactions to the drug.
Grinbaum A, Yassur I, Avni I. The Beneficial Effect of Diclofenac Sodium in the Treatment of Filamentary Keratitis. Arch Ophthalmol. 2001;119(6):926-927. doi: