We thank Dr Quigley for his insightful comments regarding our article.
He is correct in his assertion that we did not provide a detailed review of
the literature regarding possible outer retinal involvement in glaucoma. However,
we did refer to an earlier publication by Nork et al1
in which the articles by Panda and Jonas2
and Kendell et al3 were cited. Our goal
was to provide some background information about the anterograde hypothesis
and to explain why we chose this particular experimental protocol to test
it. The hypothesis states that the effects of outer retinal injury (possibly
owing to an intraocular pressure–related decrease in choroidal circulation)
may be transmitted in an anterograde manner to adversely affect ganglion cell
survival. Although photoreceptor loss is not a necessary element for this
to take place, photoreceptor injury is.
Nork TM, Poulsen GL, Nickells RW, Ver Hoeve JN, Cho N, Levin LA, Lucarelli MJ. Selective Citation of Evidence Regarding Photoreceptor Loss in Glaucoma. Arch Ophthalmol. 2001;119(9):1391. doi: