We appreciate the letter from Drs Enzenauer and Biderman concerning
the incidence of retinal detachment in the EVS. The article published on this
topic1 showed that 8% of patients undergoing
treatment for post–cataract extraction endophthalmitis developed a retinal
detachment. The incidence of retinal detachment, an adverse effect of endophthalmitis
or its treatment, did not differ significantly between those treated with
vitrectomy and those treated with tap/biopsy. However, study data showed that
the retinal detachment rate was 11% (24/214) in those not treated with IV
antibiotics vs 5% (11/206) among eyes treated with IV antibiotics. We could
not explain the latter difference with any reasonable medical hypothesis.
We postulated that the finding of this difference might be a type I error
(ie, a false-positive finding due to chance). Statistical hypothesis testing
at the P<.05 level indicates that once in every
20 times a false positive will occur by chance alone.
Doft BH, Kelsey SF, Wisniewski SR, Barza M, Endophthalmitis Vitrectomy Study. Retinal Detachment and Culture-Proven Bacterial Endophthalmitis in the EVS. Arch Ophthalmol. 2002;120(2):230-231. doi: