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Correspondence
May 2002

Subretinal Fluid in Optic Disc Edema

Arch Ophthalmol. 2002;120(5):674-675. doi:

In reply

We appreciate Dr Hayreh's comments regarding our recent article. We are embarrassed and regret misquoting Peyman and Apple.1 In an effort to be concise, and to avoid speculation, we overly edited the sentence, which should have read as follows: Horseradish peroxidase studies indicate that subretinal fluid might arise from the vitreous,1 and flourescein dye injected into the cisterna magna showed "diffusion of flourescein from the CSF (cerebrospinal fluid) in the subarachnoid space of the optic nerve into the optic nerve and optic disc"2(p1557) and indicated "a free diffusion of the materials from the CSF in the sheath of the optic nerve into the optic nerve due to the permeable nature of the pia mater."2(p1558) We only intended to refer to some previous speculations regarding the nature of subretinal fluid caused by papilledema, and we have not concluded that spinal fluid is the source. Our conclusion was, and still is, that "the exact source of subretinal fluid in papilledema remains uncertain."3(p1290)

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