Results from AREDS provide evidence for a clinically and statistically
significant benefit of the combination of high-dose zinc and antioxidant vitamins
in reducing the risk of developing advanced AMD in persons at high risk. This
conclusion is not the result of post hoc subgroup analyses. Further review
of the clinical reasons for studying various AMD categories and the statistical
reasons for the analyses presented may help clarify this misperception.
Ferris FL, Lindblad AS, Milton RC. Age-Related Eye Disease Study Caveats. Arch Ophthalmol. 2002;120(7):997-999. doi: