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New Instrument
September 2002

Intravascular Drug Delivery With a Pulsed Liquid Microjet

Author Affiliations

From the Hansen Experimental Physics Laboratory (Drs Fletcher, Palanker, and Huie) and the Department of Ophthalmology, School of Medicine (Drs Palanker, Huie, Marmor, and Blumenkranz and Mr Miller), Stanford University, Stanford, Calif. Dr Fletcher is now with the Department of Bioengineering, University of California, Berkeley. Stanford University has applied for a patent on the pulsed liquid microjet used in this study. The inventors are Drs Fletcher and Palanker.

Arch Ophthalmol. 2002;120(9):1206-1208. doi:10.1001/archopht.120.9.1206
Abstract

  Occlusions of the retinal veins and arteries, associated with diseases such as hypertension and arteriosclerosis, are a major cause of severe and irreversible loss of vision. Treatments for retinal vascular diseases have been unsatisfactory owing in part to the difficulty of delivering drugs to the site of disease within the eye. In this article, we demonstrate that a new device, the vapor bubble–driven pulsed liquid microjet, can deliver drugs into the lumen of small vessels such as those found in the retina. A 15-µm-diameter liquid jet traveling at more than 60 m/s was shown to penetrate and deliver fluid through the wall of a blood vessel that was 60µm in diameter. Perforation of the wall of the blood vessel did not extend beyond the jet diameter.

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